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10.4049/jimmunol.1500679 41 LiC.ZhangJ.XueM.LiX.HanF.LiuX.et al (2019)

Nrf2 is responsible for regulating hundreds of antioxidant genes ( Importantly in the context of ferroptosis, almost all genes thus far implicated in ferroptosis are transcriptionally regulated by Nrf2 ( Table 1 )

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Thus, the elevated blood glucose levels lead to more production of NADH and ATP, resulting in closure of ATP-sensitive potassium channels, cell depolarization, Ca 2+ influx and culminating in insulin secretion

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