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Safety across the full program was consistently favorable: adverse events, primarily mild headache and gastrointestinal symptoms, occurred at rates comparable to placebo, with no treatment-related discontinuations, no IGF-1 elevation, and no impact on glucose metabolism

Adding fasting stress during this window significantly increases the risk of severe nausea, electrolyte imbalance, and poor medication tolerance

In rat pituitary cell cultures, CJC-1295 No DAC demonstrated 49-fold greater potency than native GHRH, representing the most potent GHRH analog in in vitro systems at the time of its characterization

"Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line"