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The pivotal SURPASS clinical trial program evaluated tirzepatide in various combinations, including with metformin

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all purchased from Qiagen): GLP-1R 4 sense, 5-ggaacuccaacaugaacuatt-3 and GLP-1R 4 antisense, 5-uaguucauguuggaguucctg-3

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In the animal model of sarcopenic obesity (SO), activating the AMPK/PINK1/Parkin-mediated mitophagy pathway can effectively regulate glucolipid metabolism and improve skeletal muscle atrophy, thereby repairing the mitochondrial structure and function in muscle tissue [46]