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Giacomini KM, Huang SM, Tweedie DJ et al (2010) Membrane transporters in drug development
That has two practical sides
GLP-1 neurons that target one region, such as the hypothalamus, thalamus, or bed nucleus of the stria terminalis, have axon collaterals that branch widely and reach every central target that is known to receive GLP-1 input, including the spinal cord
But that could soon change
GLP-1 medications are FDA-approved for chronic weight management in adults with a BMI of 30 or greater, or a BMI of 27 or greater alongside at least one weight-related condition, such as high blood pressure, Type 2 diabetes, or high cholesterol
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