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The NNMT enzyme it inhibits is constitutively expressed in adipose tissue and liver, meaning timing relative to meals is less critical than consistency

N Engl J Med 384:17421751 Maselli DB, Camilleri M (2021) Effects of GLP-1 and its analogs on gastric physiology in diabetes mellitus and obesity

The drug has not fully cleared, and receptors have not had adequate time to recover

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This study demonstrates that adults who meet the FDA-approved indications for semaglutide treatment will likely benefit from the medication in multiple ways, especially if they incorporate diet and exercise improvements into their treatment regimen