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Nevertheless, the target for GIPR antagonists is believed to be a neuronal population in the brain, as a peptideantibody conjugate that blocks GIPR while activating GLP-1R required central GIPR for maximal weight loss in DIO mice, as determined using mice lacking Gipr in cells expressing synapsin 12

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2.4 mg Weeks 17+ (Wegovy only) Maximum Wegovy dose

Possible combination research: co-study with probiotics has been proposed, though this is speculative