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Poor hydration on GLP-1s can worsen constipation, nausea, dizziness, and headaches by allowing stool to harden and blood volume to drop

Parenteral thiamine can in rare instances trigger an acute allergic response characterized by hypotension, breathlessness, itching, and swelling

[19] The genomic effects of prednisone may include upregulation of anti-inflammatory proteins and downregulation of pro-inflammatory mediators

Either way, the practical implication is similar, and it is arguably the most consequential consideration for anyone planning future work: on the brain-access hypothesis, novel dual GLP-1/GIP agonists engineered specifically for brain entry would be more rational next candidates to test than repurposed diabetes drugs chosen for market availability

We can use SURMOUNT 3 as a reference within the surmount program to confirm the effectiveness of TZP in improving tension values