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Researchers observed that MC1R activation by MT-1 stimulates adenylyl cyclase, increasing intracellular cAMP, which activates CREB (cAMP response element binding protein) and induces MITF (microphthalmia-associated transcription factor) expression

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It increases the risk for multiple metabolic complications including type 2 diabetes (T2D), metabolic-dysfunction associated steatotic liver disease (MASLD, previously known as non-alcoholic fatty liver disease), cardiovascular disease as well as many mechanical complications such as osteoarthritis and obstructive sleep apnoea (OSA) [3]