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doi: 10.1126/science.1840698 120 NishiEKlagsbrunM
Weekly prescription drug data shows Zepbound has seen a surge in uptake since its recent FDA approval
Potential explanations include differences in the type of patients included, adherence to study treatment, sample size, duration of drug exposure, and GLP1 receptor activation with greater HbA1c reduction with longer-acting human GLP1-based analogs than with some short-acting exendin-4 analogs
Genetic factors, adherence to lifestyle modifications, baseline metabolic health, and age all influence where within this range a man falls
The 465nm LED excites (signal) calcium-dependent GCaMP8f fluorescence to provide a proxy for neural activity, while the 405nm LED (isosbestic) excites calcium-independent GCaMP8f fluorescence to control for movement and fiber bleaching
