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At therapeutically and research-relevant doses, MC4R is the primary pharmacologically active receptor both because it has the highest CNS expression density in regions governing sexual behaviour and because MC1R-mediated pigmentation effects (the basis of the tanning response to MT-II) are substantially attenuated in PT-141s cyclic structure
They include type 2 diabetes, obesity, cardiovascular event risk reduction, obstructive sleep apnea, chronic kidney disease, and metabolic dysfunction-associated steatotic liver disease
doi: 10.1056/NEJMoa1612917 16 GreenJBHernandezAFDAgostinoRBGrangerCBJanmohamedSJonesNPet al
E., McAllister, M
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