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The Akt pathway in oncology therapy and beyond

10.5511/plantbiotechnology.18.0205a 169 WallerF.AchatzB.BaltruschatH.FodorJ.BeckerK.FischerM.et al

Preclinical studies indicate that NNMT knockdown or inhibition can protect against diet-induced weight gain and improve metabolic parameters without reducing food intake [8] [9]

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Oxidative stress in the TME has multiple effects on cancer development, including DNA damage, genomic instability, tumor growth and proliferation, immune evasion, angiogenesis and metastasis, and therapy resistance