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We also saw more reports of hypersensitivity-type reactions, such as urticaria, than we anticipated, which raises interesting questions about possible immune-related mechanisms. Researchers also calculated the proportional reporting ratio (PRR) comparing adverse event rates between GLP-1 receptor agonist and DPP-IV inhibitors

And so these co-primary endpoint data demonstrate or defend the story that glucagon agonism can have a unique benefits in liver disease through the direct hepatic effects by increasing lipid oxidation, reducing lipogenesis that is in part weight independent

A Cochrane network meta-analysis protocol has been registered to formally synthesize these comparisons, although completed pooled estimates are not yet available [35]

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