Immunohistochemical staining demonstrated partial Cyclin D1 expression, supporting functional activation of the MAPK pathway, whereas no mTOR staining was observed (Figures 2F,G), consistent with the epigenetic findings
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Moreover, preferential staining with p-FAK [Y861], p-AKT [S473], and also p-Tyr antibody (similar to that of c-MET and p-MET) was seen along the invasive front in SCLC (Figures 5D and E)
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