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An increase in the renal production of ammonia could be another factor that contributes to the development of hyperammonaemia in VPA-treated patients

Micro-needle muscle biopsy Muscle biopsy samples were obtained by an experienced physician or trained delegate as described previously [27]

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When at least one follicle 14 mm of diameter was observed, pituitary suppression was initiated with a GnRH antagonist (0.25 mg of cetrorelix acetate, Cetrotide

While effective in structured scenarios, these methods often failed to capture complex nonlinear relationships in clinical data