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Tetramethyl bisphenol A, a bisphenol analog, is used as a fire retardant, and it inhibits testosterone synthesis in late puberty by inducing ferroptosis in Leydig cells [112]

The compound has been found to operate in the postrema and nucleus of the hindbrain solitary tract in order to both induce satiety and regulate appetite by acting on receptors found in the laterodorsal tegmental nucleus, ventral tegmental area, and the hypothalamus [1]

Furthermore, lack of sleep increases afternoon and evening stress signaling, increasing cortisol production, which contributes to suppression of testicular function as well as metabolic disturbance

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