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1 ESSENCE Clinical Trial This approval is supported by results from the phase 3 ESSENCE trial (NCT04822181) that evaluated the effect of once-weekly subcutaneous semaglutide 2.4 mg in adults with non-cirrhotic MASH and stage 2 or 3 liver fibrosis
Different retatrutide trials enroll different populations, including people with obesity, type 2 diabetes, severe obesity and cardiovascular disease, osteoarthritis or obstructive sleep apnea
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Glucagon A hormone that signals the liver to release stored glucose
![Composite primary outcome in PIONEER 6 [25]. Cumulative incidence plots](https://www.researchgate.net/publication/343772424/figure/fig1/AS:1024481283817472@1621266780897/Composite-primary-outcome-in-PIONEER-6-25-Cumulative-incidence-plots-for-the-primary.png)
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