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He told MNT that he hopes these findings dont dampen enthusiasm for the broader line of inquiry. In particular, he told us that he is encouraged by the potential of GLP-1 agonists when combined with lifestyle modification as a preventive strategy to reduce dementia risk before symptoms emerge, where the biology may be far more modifiable. Although the Evoke studies, on paper, failed, there is still hope

Circulation 136(1):2023

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Alternative Management Strategies When medication cessation is not optimal, several alternative strategies can mitigate aspiration risk whilst preserving therapeutic benefits