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We don't know the exact mechanisms yet of how these medications influence alcohol consumption, but our guess is that GLP-1 drugs can reduce the release of dopamine in the brain's motivation center, making previously rewarding behaviors, like over-drinking, less enjoyable, says Michelle Cardel, Ph.D., M.S., RD, chief nutrition officer at WeightWatchers
For a quantitative insight, this finding was further confirmed by flow cytometry (flow cytometry plots: Fig
O'Neil PM, Birkenfeld AL, McGowan B et al
TRIUMPH-1 confirmed dysesthesia as a finding across the program, at 12.5% at 12mg lower than TRIUMPH-4's rate
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