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The function of NRF2 is ubiquitously conserved across different cell types, but it is widely expressed in the central nervous system (CNS), where it regulates a range of functions including redox balance, xenobiotic metabolism, inflammation, and proteostasis (Cuadrado 2022)
Available online at: (Accessed August 27, 2025)
A big reason is vitamin B6s role in helping make hemoglobin
Some studies indicate that higher doses (120150 mg/kg) of Melatonin may impair Rota rod performance or show limited efficacy, showing the importance of dose consideration (Arreola-Espino et al
It also differentiates painful versus painless DN, showing greater nerve loss in symptomatic patients [42]
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