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For patients experiencing heart rate increases on semaglutide, several management strategies can help minimize symptoms and ensure safe continuation of therapy when clinically appropriate
Blood sugar is stable
These studies suggest that GLP-1RA may inhibit TCR signaling in a GLP-1R-dependent manner, thereby reducing systemic and intestinal inflammation induced by CD8 + T cells and other factors (anti-CD3 induction) (99)
It helps regulate blood sugar by stimulating insulin release, slowing down gastric emptying, and reducing glucagon (a hormone that raises blood sugar)
GLP-1 medications also arent recommended if youre pregnant, planning to become pregnant, or breastfeeding
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