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In the case of mPGES-2, the difference comes from the presence of an N-terminal membrane-anchoring region and of an insertion of about 40 residues between the 4 and 5 helices (Figure 3B)
PMID: 40849303 Nat Commun A UFD1 variant encoding a microprotein modulates UFD1f and IPMK ubiquitination to play pivotal roles in anti-stress responses
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this phenomenon has been linked with the increased resistance at doxorubicin treatment due to the lack of CT2 in the cell membrane that, in turn, impairs drug entry into cancer cells (Novak et al., 2015)
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