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Results Validation of Transfection of GSTP1 in HepG2 Cells To evaluate the role of GSTP1 in protecting against QIs-induced cellular perturbations, HepG2 cells were transiently transfected with a DNA construct containing the human GSTP1 cDNA behind a CMV-promoter
Recent evidence also demonstrates the dual role of nicotine, which primarily promotes hepatocarcinogenesis through activation of multiple oncogenic signaling cascades, including 7-nicotinic acetylcholine receptor (7-nAChR)/JAK2/STAT3, CYP1A1/PI3K/Akt signaling mediated by NF-B and AP-1, SETDB1/CDK6-mediated STAT1 stabilization, GCF2-driven Wnt/-catenin/SOX2 signaling, and the 2-adrenergic receptor (2-AR)/PI3K/Akt pathway [35,36,37]
A prospective study has demonstrated an association of phylloquinone and dihydrophylloquinone (but not menaquinone) intake with a lower risk of pancreatic cancer (97)
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