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8 weeks (0.251.0 mg/wk): ~1 vial 12 weeks (gradual to 1.7 mg/wk): ~2 vials 16 weeks (gradual to 2.44.5 mg/wk): ~3 vials Insulin Syringes (U-100, 1 mL) Per week: 1 syringe (once-weekly dosing) 12 weeks: 12 syringes 24 weeks: 24 syringes 48 weeks: 48 syringes Bacteriostatic Water (10 mL bottles) Use 2.0 mL (gradual) or 1.0 mL (advanced) per vial for reconstitution
These include: Pre-existing constipation or slow transit constipation Inadequate dietary fibre intake Insufficient fluid consumption Reduced physical activity levels Concurrent medications with constipating effects (such as opioids, certain antidepressants, or iron supplements) Older age , where baseline colonic motility may already be reduced The severity of constipation often correlates with the dose of medication and may be more pronounced during dose escalation phases

A U-100 insulin syringe contains 100 marked units per 1 mL

Settasatian N, Duong M, Curtiss LK, Ehnholm C, Jauhiainen M, Huuskonen J, Rye KA

The beneficial effects of single molecule GLP-1/Gcg coagonism were also demonstrated in ob/ob mice, which had enhanced GSIS and improved glucose tolerance upon acute treatment with a GLP-1/Gcg coagonist (Gault et al., 2013)
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