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Webster AN, Becker JJ, Li C, Schwalbe DC, Kerspern D, Karolczak EO, Bundon CB, Sun H, Hao Y, Liu H, Gao F (2025) The immunomodulatory effects of GLP-1 receptor agonists in neurogenerative diseases and ischemic stroke treatment
Not the best responders
The evidence reviewed herein underscores the critical role of estrogens in maintaining neuronal homeostasis, particularly through their effects on mitochondrial efficiency, antioxidant defense, and synaptic resilience
The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimers disease
A patient who cannot tolerate the stronger drug, or cannot get it covered, may do better in real life on the option with slightly lower average efficacy but better persistence
