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Sex hormones, including estrogen and progesterone, play a crucial role in various functions such as endometrial differentiation, myometrial quiescence, cervical closure, local immunotolerance in the pregnant uterus ( Placenta function in decidualization and implantation In species with hemochorial placentation, the placenta must invade the endometrial spiral arteries to create sufficient blood supply for nourishing the developing embryo

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