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Anecdotal reports suggest UTI risk is highest during the initial weeks and during dose increases, which aligns with when GI side effects (and therefore dehydration risk) are most pronounced
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Typical Protocol: Common research protocols use a loading phase of roughly 4-8 mg per week (split into 2-3 subcutaneous injections) for 4-6 weeks, followed by a maintenance phase of about 2-6 mg biweekly for another 4-8 weeks, with a full cycle running 8-14 weeks and at least 4 weeks off before repeating
Nakamura et al
Reviews the importance of thiamin in carbohydrate metabolism and cellular energy production
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