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This breakthrough led to the creation of Melanotan 1, a synthetic analog of the naturally occurring a-Melanocyte-Stimulating-Hormone (a-MSH)

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Park JJ, Gao B, Beecroft C, Wilkinson KJ, Parsonson A, Zhang K, Yan X, Wang N (2024) Safety and efficacy of JSKN003 in patients with advanced/metastatic solid tumors: A first-in-human, dose-escalation, multicenter, open-label, phase I study

As creatinine is a breakdown product of creatine phosphate, reduced levels suggest rapid depletion of muscle energy stores during seizures, consistent with increased overall energy demand 34