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Both drugs are designed to activate two different sensors in the body that help control metabolism

In people without diabetes, DPP-4 breaks down incretin hormones to balance blood sugar and insulin levels

Estos efectos sobre la conducta alimentaria se deben a la interaccin con reas del cerebro como el hipotlamo y el sistema lmbico, que son cruciales en la regulacin del apetito y las emociones

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Notably, when RNF4 was incubated with the CCW16-based PROTAC 2a , we also observed the formation of a covalent bond between 2a and RNF4 at cysteine C91 ( Figure 3D (pink), Supplementary Figure 3C )