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Acute neuroprotection (the primary outcome) was assessed by a grip strength test and by quantifying stroke volume and the number of surviving neuronal nuclear marker (NeuN)-positive neurons

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At cohort entry, we excluded patients who were less than 18 years of age, had less than one year of medical history in the database, had no diagnosis of type 2 diabetes, had contraindications such as end stage renal disease or multiple endocrine neoplasia, or had concurrent prescriptions for both a GLP-1 receptor agonist and the comparator drug