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The potential for weight loss is interesting, but I think the most interesting reason to pursue glucagon agonism in a multi-receptor agonist is the possibility that you could alter hepatic liver metabolism and potentially decrease fatty acid accumulation and hypertriglyceridemia.
The STEP 1 trial, which tested semaglutide 2.4mg in adults with obesity, found that approximately 39% of weight lost was lean mass after 68 weeks
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At various time intervals, the GSH was measured by reaction with an excess of 5-5'-dithiobis-2-nitrobenzoic acid (DTNB)
However, if reactions become increasingly severe, widespread, or are accompanied by systemic symptoms, medical review is necessary
