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It takes the best of both strategies and applies them to the appropriate phase of treatment

When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before

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In this group, sermorelin can help with both diagnosis and treatment of hGH deficiency

Some patients benefit from remaining on the lower dose for longer periods to allow better gastrointestinal adaptation