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Obesity with Comorbidities: A BMI of 30 or greater, accompanied by a documented diagnosis of heart failure, uncontrolled hypertension (high blood pressure), or chronic kidney disease
Furthermore, it reduces emptying of the stomach
The exact mechanisms through which activation of THR improves MASH are still unclear but are known to control fat synthesis, regulate fatty acid oxidation, regulate cholesterol metabolism, improve mitochondrial function, and reduce inflammation and fibrosis
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