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Increased ROS levels can lead to lipid peroxidation, protein modification, and DNA damage, exacerbating neuronal injury

Cardiovascular effects vary by timing of treatment initiation, age, and individual health history

Docking to Protein.pdb was performed in MOE using TriangleMatcher and London G scoring

however, its exact contribution to brain Se transport was not systematically studied and it seems to be rather limited since megalin / mice do not exhibit neurological phenotype associated with Se deficiency (Kurokawa et al., 2014b), typical for Selenop / or Lrp8 / mice

If staff cannot maintain identical preparation, timing, storage, and administration steps across study days, the protocol may add noise instead of insight