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Novo Nordisks presence as one of the top filers is unsurprising given its dominating role in the weight-loss drug market due to the proprietary status of Wegovy and Ozempic
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In addition, nicotinamide, the primary NNMT substrate 95,96 , is broken down by Lactobacillus arabinosis into nicotinic acid and ammonia 56
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Careful dose escalation under medical supervision helps minimise side effects and improves long-term tolerability
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