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2 TRIUMPH-1 is the larger, longer trial that confirms those earlier results
The dual action mechanism provides synergistic effects: while GLP-1 acts on insulin secretion and glucagon inhibition, GIP potentiates insulin sensitivity and improves lipid response (NEUMILLER et al., 2020)
600 In a multicenter, randomized, double-blind, placebo-controlled trial, canagliflozin did not affect the risk of neuropathy events
The effect on truly "stubborn" subcutaneous fat (which is resistant due to higher alpha-2 adrenergic receptor density) is unclear
Current consensus definition: Prevalence, etiology, and consequences
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