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Subcutaneous administration in normal and metabolically dysregulated mice significantly inhibits NNMT activity in metabolically active tissues (adipose, liver, muscle), increases systemic NAD+ levels, enhances mitochondrial function, and improves energy metabolism

Although GSH is rapidly oxidized to GSSG, the activity of e-GST remained unchanged, indicating a strong resistance to oxidants (Figure 3)

These vitamins are essential cofactors in energy metabolism, myelin integrity, and neurotransmitter synthesis

In some patients, insulin sensitivity may be reduced, as GH tends to raise blood glucose by antagonizing insulin