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The process is driven in part by genes in what's known as the "mitochondrial respiratory chain complex," a group of enzymes that help convert oxygen, sugar, and proteins into ATP through a process called oxidative phosphorylation

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Versus sulphonylureas (such as gliclazide), GLP-1 receptor agonists offer comparable glucose-lowering efficacy but with significantly lower hypoglycaemia risk and the advantage of weight loss rather than weight gain