Mechanistically, capsaicin activates endothelial TRPV4 and intermediate-conductance Ca 2+ -activated potassium channels, which induce membrane hyperpolarization and promote vasorelaxation (133)
Those are real numbers from real people - but they're self-reported, they're not from a controlled trial, and they vary enormously depending on who you are, what medication you're on, how consistently you use it, and a dozen other factors
Selective melanocortin-1 receptor (MC1R) agonist investigated
Dose-equivalence claims require direct comparative studies measuring relevant outcomes
And audiences reward familiarity over credentials: a 2026 global survey found nearly two-thirds of people who already trust a favourite lifestyle influencer would extend that trust to a brand the influencer vouches for, even one theyd otherwise distrust