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Semaglutide, the active ingredient in Wegovy and Ozempic, has strong clinical evidence for weight loss, though clinical trials showed tirzepatide achieved 20.2% average weight loss compared to semaglutide's 13.7%

The article states that these peptide molecules are too large and too rapidly metabolised to accumulate in standard serum assays, and that clinical labs do not routinely test for their presence at all

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