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In a recent study, inhibition of TH by low-dose -MT initiated at the early stage was able to prevent LRRK2 G2019S mutation-induced DA neurodegeneration in in vivo PD models [44, 164]
Others report mild decreases during the initial days of use
There is some evidence that the diabetes drug metformin (Glucophage) may reduce vitamin B12 absorption when used for several years
Ann Clin Biochem Int J Lab Med 52(4):448455 Castro R, Rivera I, Ravasco P, Jakobs C, Blom HJ, Camilo ME, de Almeida IT (2003) 5,10-Methylenetetrahydrofolate reductase 677CT and 1298AC mutations are genetic determinants of elevated homocysteine
Supplementation For more severe Vitamin B12 deficiencies, or when dietary changes alone are not effective, supplementation becomes the best treatment option
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