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For licensed GLP-1 receptor agonist medicines used for weight management (Wegovy and Saxenda), the side effect profile is well characterised in their UK Summaries of Product Characteristics (SmPCs), available via the electronic Medicines Compendium (emc)

This includes the following patient groups: - Those who follow a strictly vegan diet - Those over the age of 50 - Those who take certain medications that are known to inhibit the absorption of B12 - Those who have an autoimmune disorder - Those who have gastrointestinal disorders - Those who have issues with stomach ulcers, atrophic gastritis, and other similar health problems SYMPTOMS OF A B12 DEFICIENCY Whether you fall into any of the categories above or not, there are certain signs to be aware of that could mean that you are suffering from a vitamin B12 deficiency

Peptides may reduce symptoms while used but don't cure the underlying immune dysregulation

Even experienced users should start at the beginning of the escalation protocol and let their body adapt to this specific triple-agonist mechanism

Weeks 1 through 4: 0.25mg per week (1mg total used over 4 weeks) Weeks 5 through 8: 0.5mg per week (2mg total used over 4 weeks) Weeks 9 through 12: 1.0mg per week (4mg total used over 4 weeks) Weeks 13 through 16: 1.7mg per week (6.8mg total used over 4 weeks) Week 17 onward: 2.4mg per week (maintenance dose) During the first four weeks at 0.25mg weekly, you use only 1mg from your 10mg vial