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Studies have shown topical methods to be effective in skin lightening

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A method for reducing or alleviating one or more conditions or symptoms associated with glutathione deficiency, increased oxidative stress, and/or increased inflammation, comprising: orally administering an effective of amount of S-acetyl-glutathione (SAG) to an individual in need of such treatment

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Several pathways, including catalase and superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GPX), can inhibit lipid peroxidation [54]