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BMJ 347:f5934 OBrien PE et al (2019) Long-term outcomes after bariatric surgery: a systematic review and meta-analysis of weight loss at 10 or more years for all bariatric procedures and a single-centre review of 20-year outcomes after adjustable gastric banding

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ASK1 is currently considered as a target site for NASH therapy 38,39 , and ASK1 signalling is abnormally active in the liver of NAFLD and obese individuals

The accumulation of intracellular ROS caused by low levels of tert-butyl hydroperoxide can induce the activation of p53 and lead to cell death, which can be specifically inhibited by the ferroptosis inhibitor Fer-1 but cannot be inhibited by other kinds of cell death pathway inhibitors, indicating that the form of death is ferroptosis

During periods of starvation, both alanine and glutamine serve as key gluconeogenic amino acids, and are ultimately converted to oxaloacetate to initiate gluconeogenesis 71