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Moreover, eccDNAs derived from LTR/Copia, Ty3-retrotransposons, and Helitron elements vary across tissues, developmental stages, and epigenetic mutant backgrounds (Zaidi et al., 2025), further linking TE mobilization, methylation state, and eccDNA biogenesis

CONCLUSION: In spite of widespread reported use, there are no studies of IV GSH use for skin lightening or of its safety for chronic use (for any indication)

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