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Intracellular succinate can also be exported to the extracellular space and enter the circulatory system, such as in skeletal muscle cells, where succinate can be secreted into the extracellular milieu by MCT1 and bind to the succinate receptor-1 (SUCNR-1) on non-myofibrillar resident cells, activating downstream signaling pathways like ERK1/2 and PI3K-AKT [75, 76]

Dietary and Lifestyle Risk Factors Certain diets and lifestyle factors also increase the risk of B12 deficiency

Liu D, Lin J, Su J, Chen X, Jiang P, Huang K

PMID: 35460727 Int J Biol Sci 2022 Jan 1;18(2):717-730