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Oxidative stress, characterized by an overproduction of reactive oxygen species (ROS), disrupts the balance of glutathione within liver cells, leading to glutathione deficiencya common feature in these liver conditions

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Significant ANOVA/KruskalWallis test results were then followed with post-hoc testing, which underwent the two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli correction for multiple comparisons

[3] Bhatt DL et al

Moreover, NO seems to be the only mediator of cell proliferation arrest through the ERK1/2-p53 signaling pathway ( FIGURE 1 Next to this evidence, in our laboratory it has been demonstrated that GSH depletion modulates the peroxisome proliferator-activated receptor gamma, co-activator 1 alpha (PGC-1) expression and its downstream metabolic pathway in neuronal and skeletal muscle cells ( Figure 1 )