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STEP Trials : These trials focused on the weight management aspect of GLP-1 therapy

To achieve therapeutic efficacy, maintaining viable cell counts at the recommended dosage (10^ 9 CFU) during both aerobic storage and gastrointestinal delivery remains essential [123]

Methods The systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement for traditional pairwise meta-analysis and the PRISMA extension for network meta-analysis.89 The study protocol was prospectively registered (PROSPERO CRD 42021271647)

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