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Mid-dose formulation (7.5mg/46mg) produced 8.1% weight reduction

PubMed Kang, E.A., Han, Y.M., An, J.M., Park, Y.J., Sikiric, P., Kim, D.H., Kwon, K.A., Kim, Y.J., Yang, D., Tchah, H., & Hahm, K.B

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This means oral formulations require much higher nominal doses to achieve similar blood levels

Starting with lower doses and gradually increasing may improve tolerance