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Notably, there were no hepatic decompensations or increased side effects in the semaglutide group, suggesting that GLP-1 agonists are likely safe in compensated cirrhosis
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Patients at the 6-month mark overwhelmingly describe the decision to start as one of the best they made for their health
Some researchers posit that this effect occurs via an intrinsic mechanism, while others hypothesize that it may be mediated through the paracrine actions of insulin or somatostatin
Lastly, it is notable that the liquid medium routinely used for induction of gliotoxin biosynthesis (i.e., Czapek-Dox) provides a zinc-limiting culture condition (Saleh et al., 2018), which strongly suggests that zinc starvation could be the primary stimulus that triggers the ZafA-mediated induction of gliZ expression and, hence, gliotoxin biosynthesis, whereas the function of GliZ would be dedicated to maintain steady expression levels of the gli genes and gliotoxin biosynthesis while zinc starvation persists
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