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2020b), OTS-167 (Allegretti et al
Slow, Structured Titration: Doses start low and increase gradually over weeks to minimize side effects
Neuroendocrine Rebalancing Central GLP-1 receptor activation modulates hypothalamic circuits related to energy and reproductive signaling, including interactions with kisspeptin and gonadotropin neurons
Semaglutide escalates from 0.25mg 0.5mg 1.0mg 1.7mg 2.4mg in 4-week steps (5 levels)
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